Myocardial Remodeling and Regional Function (ReFoRM)
RESEARCHERS INVOLVED
| Permanent Researchers | Associated researchers | Non-permanent researchers |
|
Claire MAUFRAIS-BUISSON (PhD, MCU) Philippe OBERT (PhD, PU) Stéphane NOTTIN (PhD, PU-HDR) Sandrine GAYRARD (Assistant Eng. 30 %) |
Falah Aboukhoudir (MD, Cardiologist) Roland Carlioz (MD, Cardiologist) Cécile de France (MD, Cardiologist) |
Anthony Birat (PhD Student) Christophe Hédon (MD, PhD Student) |
OBJECTIVES
This group aims to assess myocardial remodeling and regional function in response to prophylactic approaches including physical exercise and nutrition in both healthy subjects (sedentary people or athletes) and patients presented with cardiovascular and cardiometabolic diseases. Based on up-to-date cardiac imaging technologies and biomarkers, researchers want to get insight into a comprehensive approach of the myocardial responses (at rest and under pharmacological or physiological stresses) to acute and chronic exercise combined, or not, with nutritional strategies. Using skills and knowledge from the other groups of the unit, we can propose a translational research approach (from cell to human) to analyze myocardial remodeling and regional function both in humans and rodents.
MAIN RESEARCH INTERESTS
The researchers of this group have the following main research interests:
- To appreciate the impact of metabolic diseases (e.g. diabetes, obesity) on the myocardial remodeling and regional function and the benefits of exercise training and/or nutritional strategies in this population,
- To understand the physiologic cardiovascular response to acute physical exercise and different types of exercise training (e.g. endurance, resistance) in healthy people,
- To evaluate the potential benefits of nutritional strategies and exercise training on the prevention and rehabilitation in cardiac disease (e.g. coronary artery disease, heart failure, cardiorenal disease)
« Le mouvement du cœur est si complexe qu’il ne peut être compris que par Dieu » Sir William Harvey « Essai anatomique sur les mouvements du cœur et des vaisseaux chez les animaux » 1628.
MATERIALS AND METHODS
Clinical study:
- High resolution echocardiography at rest and during stress conditions (exercise, dobutamine, …):
- Myocardial remodeling
- Ventricular and atrial normal myocardial strains
- Twist-untwist mechanism
- Intra/interventricular synchronism
- Myocardial work
- Biological markers (blood and urinary samples):
- Glucide and lipid profiles
- Inflammatory cytokines
- Métabolomics
- Oxidative stress
- Micro-RNA
- Heart rate variability
- Cardiopulmonary exercise testing:
- Pulmonary gas exchange (including maximal oxygen uptake, VO2max)
Experimental study:
- High resolution echocardiography in rodents:
- Myocardial remodeling
- Global systolic and diastolic function
- Ventricular and atrial normal myocardial strains
INTERNATIONAL AND NATIONAL COLLABORATIONS
- UMR 6602 – CNRS CaVITI, Thérapie Guidée par l’Image ; Institut Pascal ; Université Clermont Auvergne.
- UMR CNRS 9267 – INSERM U1046 PhyMedEX, Université de Montpellier.
- Universidad Miguel Hernández de Elche, Departments of Applied Biology and Biotechnology.
- Université Clermont Auvergne, AME2P, F-63000 Clermont-Ferrand, France.
- Fédération Française Triathlon, F-93210 Saint Denis, France.
- Centre de Ressources et d’Expertise de la Performance Sportive (CREPS), F-03700 Bellerive-sur-Allier, France.
- EA 3920 Prognostic markers and regulatory factors of cardiovascular diseases and Exercise Performance, Health, Innovation platform, Univ. of Bourgogne Franche-Comté, France.
- EA 4267 PEPITE and Exercise Performance Health Innovation Platform, Univ. of Bourgogne Franche-Comté, France.
- LIBM, Inter-university Laboratory of Human Movement Science, University Savoie Mont Blanc, Chambéry, France.
PRINCIPALES PUBLICATIONS